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Neuro-Developmental diseases

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Inflammatory intestinal diseases

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Neurodegenerative diseases

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Pelvic digestive functional disorders

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Infectious disease
Emerging axis

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Animal models

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Digestive and behavioural functionnal exploration

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Organoids

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Innovative imaging

ADN

Bioinformatic

Last selected Publications

The short-chain fatty acid butyrate prevents gut-brain amyloid-β pathology and neuroinflammation in an Alzheimer mouse model. Brossaud R, Oullier T, Bessard A, Aubert P, Brossard L, MahéM, Caillaud M, Delfino G, Paillusson S, Falentin H,  Naveilhan P, Le-Loir Y, Paillé V, Neunlist M, Cissé M. Mol Psychiatry​ 2026 Mar 5. doi: 10.1038/s41380-026-03522-6. Link

 

Delfino G, Briand JB, Oullier T, Nienkemper L, Greig J, Véziers J, Neunlist M, Derkinderen P, Paillusson S. Characterisation of Mitochondria-associated ER membranes in the enteric nervous system under physiological and pathological conditions. Am J Physiol Gastrointest Liver Physiol. 2024 Jan. Link

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Pellegrini C, Fornai M, D'Antongiovanni V, Antonioli L, Bernardini N, Derkinderen P. The intestinal barrier in disorders of the central nervous system. Lancet Gastroenterol Hepatol. 2023 Jan;8(1):66-80. Link

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Blin J, Gautier C, Aubert P, Durand T, Oullier T, Aymeric L, Naveilhan P, Masson D, Neunlist M, Bach-Ngohou K. Psychological stress induces an increase in cholinergic enteric neuromuscular pathways mediated by glucocorticoid receptors. Front Neurosci. 2023 Feb 14;17:1100473. Link

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Durand T, Paul-Gilloteaux P, Gora M, Laboudie L, Coron E, Neveu I, Neunlist M, Naveilhan P. Visualizing enteric nervous system activity through dye-free dynamic full-field optical coherence tomography. Commun Biol. 2023 Mar 2;6(1):236. Link

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Caillaud M, Le Dréan ME, De-Guilhem-de-Lataillade A, Le Berre-Scoul C, Montnach J, Nedellec S, Loussouarn G, Paillé V, Neunlist M, Boudin H. A functional network of highly pure enteric neurons in a dish. Front Neurosci. 2023 Jan 6;16:1062253. doi: 10.3389/fnins.2022.1062253. Link

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“The Enteric Nervous System in Gut and Brain Disorders (TENS)” research laboratory is a joint research unit (UMR Inserm 1235), a member of IMAD, and accredited by the French National Institute of Health and Medical Research (Inserm) and the University of Nantes. Led by Dr. M. Neunlist, the TENS laboratory is recognized for its research on enteric neuropathies in digestive disorders and brain disorders with digestive comorbidities. In particular, it has contributed to the emergence of new concepts regarding the gut-brain axis and the role of the gut microbiota in chronic diseases. The laboratory has a staff of approximately 60 people from diverse disciplinary backgrounds (neurobiologists, immunologists, gastroenterologists, neurologists, etc.) and offers a high-quality scientific and facilities environment. Its research activities are organized around five main areas, described below: 

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