Abstract

The overall objective of this axis is to understand the pathophysiological role of the ENS and its interaction with its microenvironment (intestinal epithelial cells, immune cells and microbiota) in inflammatory intestinal disorders. It is organized along three major projects dedicated to: 1) characterize the ENS lipidomic remodeling in inflammatory bowel diseases (IBD) and its functional impact upon the IEB as well as identify original ways to strengthen/restore intestinal epithelial barrier (IEB) functions; 2) study the role of EGC-T cell interactions in IBD post-operative recurrence, and 3) characterize the interactions between microbiota and IEB as a putative contributor to the low grade-inflammation post-operative ileus (POI).