"The Enteric Nervous System in gut and brain disorders"
Biocollection - Animal Models
Abstract
The TENS laboratory has developed numerous rodent animal models (rat, mouse) related to various digestive pathologies and has a few genetically modified mouse lines. The animals are housed in the Plateaux Expérimentaux en Santé (PES) of the SFR Bonamy; in compliance with the animal regulations in force.
Models of digestive pathology:
- Stress-related model (WAS = Water Avoidance Stress)
- Acute or chronic colitis with DSS
- Carcinogenesis (AOM ± DSS)
- Surgical model of post-operative ileus
- Humanized" model of autism via fecal microbiota transplantation
- Medullary lesion in mice with study of digestive functional consequences and bladder modifications
On all these models, we perform digestive functional explorations, behavioral studies and organoid production.
Funding
Publications
Bessard A, Cardaillac C, Oullier T, Cenac N, Rolli-Derkinderen M, Neunlist M, Venara A. Alterations of Prostanoid Expression and Intestinal Epithelial Barrier Functions in Ileus. J Surg Res. 2024 Apr;296:165-173. doi: 10.1016/j.jss.2023.12.018. Epub 2024 Jan 25. PMID: 38277953. Link
Fecal Supernatant from Adult with Autism Spectrum Disorder Alters Digestive Functions, Intestinal Epithelial Barrier, and Enteric Nervous System. Gonzales J, Marchix J, Aymeric L, Le Berre-Scoul C, Zoppi J, Bordron P, Burel M, Davidovic L, Richard JR, Gaman A, Lejuste F, Brouillet JZ, Le Vacon F, Chaffron S, Leboyer M, Boudin H and Neunlist M. Microorganisms; 2021, 9 (8), 1723. Link
Enteric Nervous System Remodeling in a Rat Model of Spinal Cord Injury: A Pilot Study. Lefèvre C, Bessard A, Aubert P, Joussain C, Giuliano F, Behr-Roussel D, Perrouin-Verbe MA, Perrouin-Verbe B, Brochard C and Neunlist M. Neurotrama Rep; 2020, 1 (1), 125-136. Link
PGI2 Inhibits Intestinal Epithelial Permeability and Apoptosis to Alleviate Colitis. Pochard C, Gonzales J, Bessard A, Mahe M, Bourreille A, Cenac N, Jarry A, Coron E, Podevin J, Meurette G, Neunlist M and Rolli-Derkinderen M. Cellular and Molecular Gastroenterology and Hepatology; 2021, 12 (3), 1037-1060. Link
Maternal protein restriction induces gastrointestinal dysfunction and enteric nervous system remodeling in rat offspring. Aubert P, Oleynikova E, Rizvi H, Ndjim M, Le Berre-Scoul C, Grohard PA, Chevalier J, Segain JP, Le Dréan G, Neunlist M and Boudin H. FASEB J, 2018, 33 (1), 770-781. Link