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Spinal cord injury

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Spinal cord injury and Spina Bifida


Résumé graphique

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Project display

This project aims 1) (i) to characterize the abnormalities of the UNGE and its microenvironment (metabolites derived from PUFAs, digestive microbiota) in medullary and cauda equina pathologies, (ii) to identify if these abnormalities are associated with clinical disorders and (iii) to identify new therapeutic targets in order to improve the management of the patients In parallel and in mirror of the digestive disorders, it aims 2) to characterize the remodeling of the urothelium and its microenvironment (lipid mediators and urinary microbiota) associated with the vesico-sphincter disorders observed in patients with spinal cord disease, in particular detrusor overactivity, in order to identify new therapeutic targets or biomarkers of response to treatment (in particular drug treatment and intra-detrusor botulinum toxin).

Researchers / Clinicians

Michel Neunlist
+33 2 40 41 28 44



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Charlène Brochard

+33 2 40 41 11 07

Chloé Lefevre
+33 2 40 41 11 07


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Philippe Aubert
+33 2 40 41 29 50

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Anne Bessard

+33 2 40 41 29 50



AOI CHU Rennes = 38 850 euros

AOI CHU Nantes = 87 000 euros

AOI Cohorte NEUDOTOX CHU NANTES : 132 410 euros

Bourse SIFUD PP ( C Chapelle) : 10 000 euros

Mécenat Allergan-Abvie : 10 000 euros

Mécénat fondation APICIL = 28 000 euros

Bourse Neurosphynx = 40 460 euros

ANR BBSCI = Remodeling of bowel and bladder functions in spinal cord injury: revisiting the role of polyunsaturated fatty acid metabolites (592 039 euros)


Enteric Nervous System Remodeling in a Rat Model of Spinal Cord Injury: A Pilot Study.

Lefèvre C, Bessard A, Aubert P, Joussain C, Giuliano F, Behr-Roussel D, Perrouin-Verbe MA, Perrouin-Verbe B, Brochard C, Neunlist M.Neurotrauma Rep. 2020 Oct 22;1(1):125-136. Link

Bowel Dysfunction Related to Spina Bifida: Keep It Simple.

Brochard C, Peyronnet B, Dariel A, Ménard H, Manunta A, Ropert A, Neunlist M, Bouguen G, Siproudhis L.Dis Colon Rectum. 2017 Nov;60(11):1209-1214. doi: 10.1097/DCR.0000000000000892.PMID: 28991086 Link


Defecation disorders in Spina Bifida: Realistic goals and best therapeutic approaches.

Brochard C, Peyronnet B, Hascoet J, Olivier R, Manunta A, Jezequel M, Alimi Q, Ropert A, Neunlist M, Bouguen G, Siproudhis L.Neurourol Urodyn. 2019 Feb;38(2):719-725. doi: 10.1002/nau.23904. Epub 2018 Dec 21.PMID: 30575995 Link


Fecal incontinence in patients with spina bifida: The target is the rectum.

Brochard C, Ropert A, Peyronnet B, Ménard H, Manunta A, Neunlist M, Bouguen G, Siproudhis L.Neurourol Urodyn. 2018 Mar;37(3):1082-1087. doi: 10.1002/nau.23417. Epub 2017 Sep 26.PMID: 28950040 Link

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