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Colorectal cancer


Characterization of the interaction between enteric neurons and tumor cells

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« Evaluation of systemic stress and its mediators, glucocorticoid hormones, on the enteric nervous system »
« Evaluation of ileus post-operative on the enteric nervous system »
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Figure: Expression of LPGDS in enteric nervous system ans specifically in neurons (Hu)

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The effects of glucocorticoids in the central nervous system are well deciphered, notably on the control of mood or memory processes (Mc Even 2007, Groeneweg 2012). In contrast, their roles in the enteric nervous system (ENS) are poorly described, yet patients without glucocorticoid hormones (by primary or secondary adrenal insufficiency) present with abdominal pain and diarrhea (Sharma ST et al, 2015). . Through the study of systemic mediators such as cortisol (in humans) and corticosterone (in mouse models), the objective of our team is to clarify the role of corticosteroids on ENS and its environment in condition physiological and pathological (irritable bowel syndrome, primary or secondary adrenal insufficiency). Under physiological conditions in rats, we have shown that glucocorticoid receptors GR are constitutively expressed by certain neurons of the ENS, and that, in parallel with an increase in corticosteronemia and intestinal permeability, stress could modulate the expression ( see figure below, unpublished data). We have an animal model that allows us to evaluate the effect of systemic stress on the ENS.

Figure: Expression of corticosterone GR receptors in enteric nervous system ans specifically in neurons (Hu) in a controlled and stressed model of Sprague Dawley (J21) rats (WAS 2h)

Researchers / Clinicians

Kalyane Bach-Ngohou


+33 2 40 08 40 05

Emmanuel Coron


+33 2 40 08 30 97

Damien Masson


+33 2 40 08 40 08

Stanislas Bruley Des Varannes


+33 2 40 08 33 06

Michel Neunlist


+33 2 40 41 28 44

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Aurélien Vénara


+33 2 40 41

ITA / Students

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Anne Bessard


+33 2 40 41 29 50


"Impact of stress on motor function through the enteric nervous system"

Camille Gautier


+33 2 40 41 29 74


Le Loupp AG, Bach-Ngohou K, Bourreille A, Boudin H, Rolli-Derkinderen M, Denis MG, Neunlist M, Masson D. Activation of the prostaglandin D2 metabolic pathway in Crohn's disease: involvement of the enteric nervous system. BMC Gastroenterol. 2015 Sep 4;15:112. doi: 10.1186/s12876-015-0338-7

Bach-Ngohou K, Mahé MM, Aubert P, Abdo H, Boni S, Bourreille A, Denis MG, Lardeux B, Neunlist M, Masson D. Enteric glia modulate epithelial cell proliferation and differentiation through 15-deoxy-12,14-prostaglandin J2. J Physiol. 2010 Jul 15;588(Pt 14):2533-44. doi: 10.1113/jphysiol.2010.188409

Abdo H, Derkinderen P, Gomes P, Chevalier J, Aubert P, Masson D, Galmiche JP, Vanden Berghe P, Neunlist M, Lardeux B. Enteric glial cells protect neurons from oxidative stress in part via reduced glutathione. FASEB J. 2010 Apr;24(4):1082-94. doi: 10.1096/fj.09-139519

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