Axis 2

Neurodevelopmental pathologies,

neurodegenerative et neurotraumatic 

Implication du SNE dans les maladies neurodéveloppementales de l'Intestin et du Cerveau.

Implication du SNE dans les maladies neurodéveloppementales de l'Intestin et du Cerveau.

Involvement of ENS in neurotraumatic pathologies

My research project in 2 min ...

Spinal cord injuries are interruptions of nerve fibers in the spinal cord, which occurs in the majority of cases (70%) after trauma (road accident, sport accident ...). In addition to paralysis of the limbs, its lesions induce disorders of other organs (vesico-sphincterian, digestive ...). To date the management of digestive disorders in patients with spinal cord injury remains largely to improve and these disorders appear in the priorities of recovery (in the 2 / 3rd position) of patients. Also, to better characterize the nature of the digestive disorders and the mechanisms underlying them, in particular the achievement of the SNE, is a priority objective of this axis. A better understanding of the plasticity of SNE in these patients will allow new therapeutic approaches to be developed. Thus, our project aims to 1) characterize in an animal model of spinal cord injury (Coll University of Saint Quentin) the remodeling of the SNE and digestive functions and 2) to characterize on colon biopsies of patients supported for constipation remodeling of the neuro-glio-epithelial unit (Consticape study).

Project display

Medullary lesion
Expression of neuromediators in the rat myenteric plexus

Researchers / Clinicians


ITA / Students

"Remodeling of the enteric nervous system in spinal cord injured patients"

Chloé Lefevre


+33 2 40 41 11 25



+33 2 40 08 33 33



Michel Neunlist


+33 2 40 41 28 44

Brigitte PV.jpg

Brigitte Perrouin-Verbe

+33 2 40 41 28 44

Ronzi Y, Le Normand L, Chartier-Kastler E, Game X, Grise P, Denys P, Perrouin-Verbe B. Neurogenic stress urinary incontinence: is there a place for Adjustable Continence Therapy (ACT™ and ProACT™, Uromedica, Plymouth, MN, USA)? A retrospective multicenter study. Spinal Cord. 2019 Jan 9. doi: 10.1038/s41393-018-0219-3

Lefèvre C, Bellier-Waast F, Lejeune F, Duteille F, Kieny P, Le Fort M, Perrouin-Verbe B. Ten years of myocutaneous flaps for pressure ulcers in patients with spinal lesions: Analysis of complications in the framework of a specialised medical-surgical pathway. J Plast Reconstr Aesthet Surg. 2018 Nov;71(11):1652-1663. doi: 10.1016/j.bjps.2018.07.007

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