Plan du site

2016 - Réalisé par ScientiWeb              Mentions légales

Digestive, Inflammatory and motor diseases

Axis 1

Interactions between ENS and the intestinal immune system during IBD.

« This research project based on the analysis of rat cells and cells from patients with inflammatory bowel disease (IBD) is important to characterize the mechanisms involved in these digestive diseases and highlight new therapeutic targets»

The enteric nervous system (ENS) plays an essential role in the homeostasis of the gastrointestinal system, and recent observations have emphasized the importance of good communication between the cells of the ENS and the cells of the immune system to maintain this equilibrium. within the digestive wall. Neuro-immune interactions are particularly critical in cases of inflammatory bowel disease (IBD) such as Crohn's disease or ulcerative colitis.

Characterizing the interactions between SNE cells (neurons, enteric glial cells) and cells of the immune system (lymphocytes, macrophages) is therefore essential to understand and prevent imbalances that affect the integrity and functioning of the immune system. 'intestine.

 

This is the goal we are looking for when studying:

:

                   1- the impact of ENS cells on the phenotype and functions of T lymphocytes

                   2- the impact of T lymphocytes on the survival and activity of neurons and enteric glial cells

                   3- how inflammation changes neuro-immune interactions within the intestinal wall

Project display

Figure: Interactions between T cells (R7.3, green), neurons (b tubulin III, red) and enteric glial cells (S100-b, purple), with nuclear staining in blue.
My research project in 1 video ...

Researchers / Clinicians

Philippe Naveilhan 

 

+33 2 40 41 29 74

philippe.naveilhan@univ-nantes.fr

Arnaud Bourreille

 

+33 2 40 08 31 52

arnaud.bourreille@chu-nantes.fr

Isabelle Neveu 

 

+33 2 40 41 29 74

isabelle.neveu@univ-nantes.fr

Guillaume Meurette

 

+33 2 40 08 31 52

guillaume.meurette@chu-nantes.fr

ITA / Students

Tony Durand

 

+33 2 40 41 29 50

tony.durand@univ-nantes.fr

"Role of ENS and inflammation in enteric plexitis formation"

Julie Pabois

 

+33 2 40 41 11 07

julie.pabois@etu.univ-nantes.fr

Publications

Kermarrec L, Durand T, Gonzales J, Pabois J, Hulin P, Neunlist M, Neveu I, Naveilhan P. Rat enteric glial cells express novel isoforms of Interleukine-7 regulated during inflammation. Neurogastroenterol Motil. 2019 Jan;31(1):e13467. doi: 10.1111/nmo

Pochard C, Coquenlorge S, Freyssinet M, Naveilhan P, Bourreille A, Neunlist M, Rolli-Derkinderen M. The multiple faces of inflammatory enteric glial cells: is Crohn's disease a gliopathy? Am J Physiol Gastrointest Liver Physiol. 2018 Mar 8. doi: 10.1152/ajpgi.00016.2018.

Lilli NL, Quénéhervé L, Haddara S, Brochard C, Aubert P, Rolli-Derkinderen M, Durand T, Naveilhan P, Hardouin JB, De Giorgio R, Barbara G, Bruley des Varannes S, Coron E, Neunlist M. Glioplasticity in irritable bowel syndrome. Neurogastroenterol Motil. 2018 Apr;30(4):e13232. doi: 10.1111/nmo.13232

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